CovidStanfordV1, Main, Exploration, bibRecord, 000526

Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2.

Identifieur interne : 000526 ( Main/Exploration ); précédent : 000525; suivant : 000527

Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2.

Auteurs : Sandra C A. Nielsen [États-Unis] ; Fan Yang [États-Unis] ; Katherine J L. Jackson [Australie] ; Ramona A. Hoh [États-Unis] ; Katharina Röltgen [États-Unis] ; Grace H. Jean [États-Unis] ; Bryan A. Stevens [États-Unis] ; Ji-Yeun Lee [États-Unis] ; Arjun Rustagi [États-Unis] ; Angela J. Rogers [États-Unis] ; Abigail E. Powell [États-Unis] ; Molly Hunter [États-Unis] ; Javaria Najeeb [États-Unis] ; Ana R. Otrelo-Cardoso [États-Unis] ; Kathryn E. Yost [États-Unis] ; Bence Daniel [États-Unis] ; Kari C. Nadeau [États-Unis] ; Howard Y. Chang [États-Unis] ; Ansuman T. Satpathy [États-Unis] ; Theodore S. Jardetzky [États-Unis] ; Peter S. Kim [États-Unis] ; Taia T. Wang [États-Unis] ; Benjamin A. Pinsky [États-Unis] ; Catherine A. Blish [États-Unis] ; Scott D. Boyd [États-Unis]

Source :

Cell host & microbe [ 1934-6069 ] ; 2020.

RBID : pubmed:32941787

Descripteurs français

English descriptors

KwdEn :
- Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Antibodies, Viral (blood), Antibodies, Viral (genetics), Antibodies, Viral (immunology), Antibody Formation (MeSH), B-Lymphocytes (immunology), Betacoronavirus (genetics), Betacoronavirus (immunology), COVID-19 (MeSH), Coronavirus Infections (immunology), Coronavirus Infections (virology), Female (MeSH), HEK293 Cells (MeSH), Humans (MeSH), Immunogenetics (MeSH), Immunoglobulin A (genetics), Immunoglobulin A (immunology), Immunoglobulin G (genetics), Immunoglobulin G (immunology), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (immunology), Pneumonia, Viral (virology), SARS-CoV-2 (MeSH), Sequence Analysis (MeSH), Spike Glycoprotein, Coronavirus (immunology).
MESH :
- chemical , blood : Antibodies, Viral.
- chemical , genetics : Antibodies, Viral, Immunoglobulin A, Immunoglobulin G.
- chemical , immunology : Antibodies, Viral, Immunoglobulin A, Immunoglobulin G, Spike Glycoprotein, Coronavirus.
- genetics : Betacoronavirus.
- immunology : B-Lymphocytes, Betacoronavirus, Coronavirus Infections, Pneumonia, Viral.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Adult, Aged, Aged, 80 and over, Antibody Formation, COVID-19, Female, HEK293 Cells, Humans, Immunogenetics, Male, Middle Aged, Pandemics, SARS-CoV-2, Sequence Analysis.

Abstract

B cells are critical for the production of antibodies and protective immunity to viruses. Here we show that patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who develop coronavirus disease 2019 (COVID-19) display early recruitment of B cells expressing a limited subset of IGHV genes, progressing to a highly polyclonal response of B cells with broader IGHV gene usage and extensive class switching to IgG and IgA subclasses with limited somatic hypermutation in the initial weeks of infection. We identify convergence of antibody sequences across SARS-CoV-2-infected patients, highlighting stereotyped naive responses to this virus. Notably, sequence-based detection in COVID-19 patients of convergent B cell clonotypes previously reported in SARS-CoV infection predicts the presence of SARS-CoV/SARS-CoV-2 cross-reactive antibody titers specific for the receptor-binding domain. These findings offer molecular insights into shared features of human B cell responses to SARS-CoV-2 and SARS-CoV.

DOI: 10.1016/j.chom.2020.09.002
PubMed: 32941787
PubMed Central: PMC7470783

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000309
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Le document en format XML

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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Chang, Howard Y" sort="Chang, Howard Y" uniqKey="Chang H" first="Howard Y" last="Chang">Howard Y. Chang</name>
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<author><name sortKey="Jardetzky, Theodore S" sort="Jardetzky, Theodore S" uniqKey="Jardetzky T" first="Theodore S" last="Jardetzky">Theodore S. Jardetzky</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Kim, Peter S" sort="Kim, Peter S" uniqKey="Kim P" first="Peter S" last="Kim">Peter S. Kim</name>
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<country xml:lang="fr">États-Unis</country>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305</wicri:regionArea>
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<author><name sortKey="Pinsky, Benjamin A" sort="Pinsky, Benjamin A" uniqKey="Pinsky B" first="Benjamin A" last="Pinsky">Benjamin A. Pinsky</name>
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<author><name sortKey="Blish, Catherine A" sort="Blish, Catherine A" uniqKey="Blish C" first="Catherine A" last="Blish">Catherine A. Blish</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Boyd, Scott D" sort="Boyd, Scott D" uniqKey="Boyd S" first="Scott D" last="Boyd">Scott D. Boyd</name>
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<country xml:lang="fr">États-Unis</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2.</title>
<author><name sortKey="Nielsen, Sandra C A" sort="Nielsen, Sandra C A" uniqKey="Nielsen S" first="Sandra C A" last="Nielsen">Sandra C A. Nielsen</name>
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<author><name sortKey="Yang, Fan" sort="Yang, Fan" uniqKey="Yang F" first="Fan" last="Yang">Fan Yang</name>
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<author><name sortKey="Jackson, Katherine J L" sort="Jackson, Katherine J L" uniqKey="Jackson K" first="Katherine J L" last="Jackson">Katherine J L. Jackson</name>
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<country xml:lang="fr">Australie</country>
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<author><name sortKey="Hoh, Ramona A" sort="Hoh, Ramona A" uniqKey="Hoh R" first="Ramona A" last="Hoh">Ramona A. Hoh</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Stanford University, Stanford, CA 94305</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
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<orgName type="university">Université Stanford</orgName>
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<author><name sortKey="Roltgen, Katharina" sort="Roltgen, Katharina" uniqKey="Roltgen K" first="Katharina" last="Röltgen">Katharina Röltgen</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Stanford University, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Stanford University, Stanford, CA 94305</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Jean, Grace H" sort="Jean, Grace H" uniqKey="Jean G" first="Grace H" last="Jean">Grace H. Jean</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Developmental Biology, Stanford University, Stanford, CA 94305</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Stevens, Bryan A" sort="Stevens, Bryan A" uniqKey="Stevens B" first="Bryan A" last="Stevens">Bryan A. Stevens</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Stanford University, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Stanford University, Stanford, CA 94305</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Lee, Ji Yeun" sort="Lee, Ji Yeun" uniqKey="Lee J" first="Ji-Yeun" last="Lee">Ji-Yeun Lee</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Stanford University, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Stanford University, Stanford, CA 94305</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Rustagi, Arjun" sort="Rustagi, Arjun" uniqKey="Rustagi A" first="Arjun" last="Rustagi">Arjun Rustagi</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA 94305</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Rogers, Angela J" sort="Rogers, Angela J" uniqKey="Rogers A" first="Angela J" last="Rogers">Angela J. Rogers</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA 94305</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Powell, Abigail E" sort="Powell, Abigail E" uniqKey="Powell A" first="Abigail E" last="Powell">Abigail E. Powell</name>
<affiliation wicri:level="4"><nlm:affiliation>Stanford ChEM-H and Department of Biochemistry, Stanford University, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford ChEM-H and Department of Biochemistry, Stanford University, Stanford, CA 94305</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Hunter, Molly" sort="Hunter, Molly" uniqKey="Hunter M" first="Molly" last="Hunter">Molly Hunter</name>
<affiliation wicri:level="1"><nlm:affiliation>ATUM, Newark, CA, 94560, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>ATUM, Newark, CA, 94560</wicri:regionArea>
<wicri:noRegion>94560</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Najeeb, Javaria" sort="Najeeb, Javaria" uniqKey="Najeeb J" first="Javaria" last="Najeeb">Javaria Najeeb</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Structural Biology, Stanford University, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Structural Biology, Stanford University, Stanford, CA 94305</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Otrelo Cardoso, Ana R" sort="Otrelo Cardoso, Ana R" uniqKey="Otrelo Cardoso A" first="Ana R" last="Otrelo-Cardoso">Ana R. Otrelo-Cardoso</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Structural Biology, Stanford University, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Structural Biology, Stanford University, Stanford, CA 94305</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Yost, Kathryn E" sort="Yost, Kathryn E" uniqKey="Yost K" first="Kathryn E" last="Yost">Kathryn E. Yost</name>
<affiliation wicri:level="4"><nlm:affiliation>Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Daniel, Bence" sort="Daniel, Bence" uniqKey="Daniel B" first="Bence" last="Daniel">Bence Daniel</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Stanford University, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Stanford University, Stanford, CA 94305</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Nadeau, Kari C" sort="Nadeau, Kari C" uniqKey="Nadeau K" first="Kari C" last="Nadeau">Kari C. Nadeau</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA 94305, USA; Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA, 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA 94305, USA; Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA, 94305</wicri:regionArea>
<orgName type="university">Université Stanford</orgName>
<placeName><settlement type="city">Stanford (Californie)</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chang, Howard Y" sort="Chang, Howard Y" uniqKey="Chang H" first="Howard Y" last="Chang">Howard Y. Chang</name>
<affiliation wicri:level="4"><nlm:affiliation>Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Satpathy, Ansuman T" sort="Satpathy, Ansuman T" uniqKey="Satpathy A" first="Ansuman T" last="Satpathy">Ansuman T. Satpathy</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Stanford University, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Stanford University, Stanford, CA 94305</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Jardetzky, Theodore S" sort="Jardetzky, Theodore S" uniqKey="Jardetzky T" first="Theodore S" last="Jardetzky">Theodore S. Jardetzky</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Structural Biology, Stanford University, Stanford, CA 94305, USA; Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA, 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Structural Biology, Stanford University, Stanford, CA 94305, USA; Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA, 94305</wicri:regionArea>
<orgName type="university">Université Stanford</orgName>
<placeName><settlement type="city">Stanford (Californie)</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kim, Peter S" sort="Kim, Peter S" uniqKey="Kim P" first="Peter S" last="Kim">Peter S. Kim</name>
<affiliation wicri:level="4"><nlm:affiliation>Stanford ChEM-H and Department of Biochemistry, Stanford University, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford ChEM-H and Department of Biochemistry, Stanford University, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Wang, Taia T" sort="Wang, Taia T" uniqKey="Wang T" first="Taia T" last="Wang">Taia T. Wang</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Pinsky, Benjamin A" sort="Pinsky, Benjamin A" uniqKey="Pinsky B" first="Benjamin A" last="Pinsky">Benjamin A. Pinsky</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Stanford University, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Stanford University, Stanford, CA 94305</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Blish, Catherine A" sort="Blish, Catherine A" uniqKey="Blish C" first="Catherine A" last="Blish">Catherine A. Blish</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA. Electronic address: cblish@stanford.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Stanford (Californie)</settlement>
</placeName>
<orgName type="university">Université Stanford</orgName>
</affiliation>
</author>
<author><name sortKey="Boyd, Scott D" sort="Boyd, Scott D" uniqKey="Boyd S" first="Scott D" last="Boyd">Scott D. Boyd</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Stanford University, Stanford, CA 94305, USA; Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA, 94305, USA. Electronic address: sboyd1@stanford.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, Stanford University, Stanford, CA 94305, USA; Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA, 94305</wicri:regionArea>
<orgName type="university">Université Stanford</orgName>
<placeName><settlement type="city">Stanford (Californie)</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Cell host & microbe</title>
<idno type="eISSN">1934-6069</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Antibodies, Viral (blood)</term>
<term>Antibodies, Viral (genetics)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Antibody Formation (MeSH)</term>
<term>B-Lymphocytes (immunology)</term>
<term>Betacoronavirus (genetics)</term>
<term>Betacoronavirus (immunology)</term>
<term>COVID-19 (MeSH)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Coronavirus Infections (virology)</term>
<term>Female (MeSH)</term>
<term>HEK293 Cells (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Immunogenetics (MeSH)</term>
<term>Immunoglobulin A (genetics)</term>
<term>Immunoglobulin A (immunology)</term>
<term>Immunoglobulin G (genetics)</term>
<term>Immunoglobulin G (immunology)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (immunology)</term>
<term>Pneumonia, Viral (virology)</term>
<term>SARS-CoV-2 (MeSH)</term>
<term>Sequence Analysis (MeSH)</term>
<term>Spike Glycoprotein, Coronavirus (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Analyse de séquence (MeSH)</term>
<term>Anticorps antiviraux (génétique)</term>
<term>Anticorps antiviraux (immunologie)</term>
<term>Anticorps antiviraux (sang)</term>
<term>Betacoronavirus (génétique)</term>
<term>Betacoronavirus (immunologie)</term>
<term>Cellules HEK293 (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Glycoprotéine de spicule des coronavirus (immunologie)</term>
<term>Humains (MeSH)</term>
<term>Immunoglobuline A (génétique)</term>
<term>Immunoglobuline A (immunologie)</term>
<term>Immunoglobuline G (génétique)</term>
<term>Immunoglobuline G (immunologie)</term>
<term>Immunogénétique (MeSH)</term>
<term>Infections à coronavirus (immunologie)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Lymphocytes B (immunologie)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (immunologie)</term>
<term>Pneumopathie virale (virologie)</term>
<term>Production d'anticorps (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antibodies, Viral</term>
<term>Immunoglobulin A</term>
<term>Immunoglobulin G</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term>
<term>Immunoglobulin A</term>
<term>Immunoglobulin G</term>
<term>Spike Glycoprotein, Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Betacoronavirus</term>
<term>Immunoglobuline A</term>
<term>Immunoglobuline G</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Betacoronavirus</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Immunoglobuline A</term>
<term>Immunoglobuline G</term>
<term>Infections à coronavirus</term>
<term>Lymphocytes B</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>B-Lymphocytes</term>
<term>Betacoronavirus</term>
<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antibody Formation</term>
<term>COVID-19</term>
<term>Female</term>
<term>HEK293 Cells</term>
<term>Humans</term>
<term>Immunogenetics</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>SARS-CoV-2</term>
<term>Sequence Analysis</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de séquence</term>
<term>Cellules HEK293</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunogénétique</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Production d'anticorps</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
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<front><div type="abstract" xml:lang="en">B cells are critical for the production of antibodies and protective immunity to viruses. Here we show that patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who develop coronavirus disease 2019 (COVID-19) display early recruitment of B cells expressing a limited subset of IGHV genes, progressing to a highly polyclonal response of B cells with broader IGHV gene usage and extensive class switching to IgG and IgA subclasses with limited somatic hypermutation in the initial weeks of infection. We identify convergence of antibody sequences across SARS-CoV-2-infected patients, highlighting stereotyped naive responses to this virus. Notably, sequence-based detection in COVID-19 patients of convergent B cell clonotypes previously reported in SARS-CoV infection predicts the presence of SARS-CoV/SARS-CoV-2 cross-reactive antibody titers specific for the receptor-binding domain. These findings offer molecular insights into shared features of human B cell responses to SARS-CoV-2 and SARS-CoV.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32941787</PMID>
<DateCompleted><Year>2020</Year>
<Month>10</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2021</Year>
<Month>01</Month>
<Day>26</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1934-6069</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>28</Volume>
<Issue>4</Issue>
<PubDate><Year>2020</Year>
<Month>10</Month>
<Day>07</Day>
</PubDate>
</JournalIssue>
<Title>Cell host & microbe</Title>
<ISOAbbreviation>Cell Host Microbe</ISOAbbreviation>
</Journal>
<ArticleTitle>Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2.</ArticleTitle>
<Pagination><MedlinePgn>516-525.e5</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S1931-3128(20)30503-5</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.chom.2020.09.002</ELocationID>
<Abstract><AbstractText>B cells are critical for the production of antibodies and protective immunity to viruses. Here we show that patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who develop coronavirus disease 2019 (COVID-19) display early recruitment of B cells expressing a limited subset of IGHV genes, progressing to a highly polyclonal response of B cells with broader IGHV gene usage and extensive class switching to IgG and IgA subclasses with limited somatic hypermutation in the initial weeks of infection. We identify convergence of antibody sequences across SARS-CoV-2-infected patients, highlighting stereotyped naive responses to this virus. Notably, sequence-based detection in COVID-19 patients of convergent B cell clonotypes previously reported in SARS-CoV infection predicts the presence of SARS-CoV/SARS-CoV-2 cross-reactive antibody titers specific for the receptor-binding domain. These findings offer molecular insights into shared features of human B cell responses to SARS-CoV-2 and SARS-CoV.</AbstractText>
<CopyrightInformation>Copyright © 2020 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nielsen</LastName>
<ForeName>Sandra C A</ForeName>
<Initials>SCA</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Stanford University, Stanford, CA 94305, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Fan</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Stanford University, Stanford, CA 94305, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jackson</LastName>
<ForeName>Katherine J L</ForeName>
<Initials>KJL</Initials>
<AffiliationInfo><Affiliation>Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hoh</LastName>
<ForeName>Ramona A</ForeName>
<Initials>RA</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Stanford University, Stanford, CA 94305, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Röltgen</LastName>
<ForeName>Katharina</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Stanford University, Stanford, CA 94305, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jean</LastName>
<ForeName>Grace H</ForeName>
<Initials>GH</Initials>
<AffiliationInfo><Affiliation>Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stevens</LastName>
<ForeName>Bryan A</ForeName>
<Initials>BA</Initials>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007125" MajorTopicYN="N">Immunogenetics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007070" MajorTopicYN="N">Immunoglobulin A</DescriptorName>
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<CoiStatement>Declaration of Interests A.T.S. is a scientific founder of Immunai and receives research funding from Arsenal Biosciences not related to this study. M.H. is an employee of ATUM. S.D.B. has consulted for Regeneron, Sanofi, and Novartis on topics unrelated to this study. S.D.B., K.R., P.S.K., and A.E.P. have filed provisional patent applications related to serological tests for SARS-CoV-2 antibodies. K.C.N. reports grants from National Institute of Allergy and Infectious Diseases (NIAID), Food Allergy Research & Education (FARE), and End Allergies Together (EAT); National Heart, Lung, and Blood Institute (NHLBI), and National Institute of Environmental Health Sciences (NIEHS), and is the director of FARE and World Allergy Organization (WAO) Center of Excellence at Stanford; advisor at Cour Pharma; co-founder of Before Brands, Alladapt, Latitude, and IgGenix; National Scientific Committee member at Immune Tolerance Network (ITN) and National Institutes of Health (NIH); a recipient of a Research Sponsorship from Nestle; Consultant and Advisory Board Member at Before Brands, Alladapt, Iggenix, NHLBI, and Probio; Data and Safety Monitoring Board member at NHLBI; and has US patents for basophil testing, multifood immunotherapy and prevention, monoclonal antibodies from plasmablasts, and devices for diagnostics. The remaining authors declare that they have no competing interests.</CoiStatement>
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</ArticleIdList>
<ReferenceList><Reference><Citation>Cell Rep Med. 2020 Jun 23;1(3):100040</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32835303</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2020 Aug;584(7819):120-124</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32454512</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2020 Jul 9;182(1):73-84.e16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32425270</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Rep. 2020 Mar 3;30(9):2963-2977.e6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32130900</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genome Med. 2016 Feb 25;8(1):23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26917418</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Protoc Microbiol. 2020 Jun;57(1):e100</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32302069</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2019 Oct 1;203(7):1687-1692</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31484734</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2020 Jun 12;368(6496):1274-1278</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32404477</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Microbiol. 2016 Jun;24(6):490-502</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27012512</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2013 Jul;41(Web Server issue):W34-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23671333</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2016 Feb 16;6:20842</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26880249</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2007 Apr 25;361(1):93-102</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17161858</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioinformatics. 2012 Dec 1;28(23):3150-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23060610</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2020 Aug;584(7821):437-442</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32555388</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2020 Aug 28;369(6507):1119-1123</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32661058</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2020 Jul;583(7815):290-295</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32422645</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Euro Surveill. 2020 Jan;25(3):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31992387</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2020 Feb 20;382(8):727-733</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31978945</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2020 May 19;323(19):1967-1969</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32250394</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Host Microbe. 2014 Jul 9;16(1):105-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24981332</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2002 Jan 15;30(2):E9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11788735</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2012 Nov 8;367(19):1814-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23075143</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Host Microbe. 2013 Jun 12;13(6):691-700</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23768493</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2019 May 30;177(6):1566-1582.e17</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31104840</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Leukemia. 2003 Dec;17(12):2257-317</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14671650</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2019 May 15;9(1):7429</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31092835</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Med. 2006 Jul;3(7):e237</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16796401</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2020 Aug;584(7819):115-119</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32454513</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioinformatics. 2011 Nov 1;27(21):2957-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21903629</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EBioMedicine. 2016 Oct;12:178-188</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27628668</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Commun. 2020 Aug 27;11(1):4303</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32855401</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2020 Feb 15;395(10223):497-506</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31986264</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Transl Med. 2019 Feb 27;11(481):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30814336</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2003 Apr 19;361(9366):1319-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12711465</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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<name sortKey="Rustagi, Arjun" sort="Rustagi, Arjun" uniqKey="Rustagi A" first="Arjun" last="Rustagi">Arjun Rustagi</name>
<name sortKey="Satpathy, Ansuman T" sort="Satpathy, Ansuman T" uniqKey="Satpathy A" first="Ansuman T" last="Satpathy">Ansuman T. Satpathy</name>
<name sortKey="Stevens, Bryan A" sort="Stevens, Bryan A" uniqKey="Stevens B" first="Bryan A" last="Stevens">Bryan A. Stevens</name>
<name sortKey="Wang, Taia T" sort="Wang, Taia T" uniqKey="Wang T" first="Taia T" last="Wang">Taia T. Wang</name>
<name sortKey="Yang, Fan" sort="Yang, Fan" uniqKey="Yang F" first="Fan" last="Yang">Fan Yang</name>
<name sortKey="Yost, Kathryn E" sort="Yost, Kathryn E" uniqKey="Yost K" first="Kathryn E" last="Yost">Kathryn E. Yost</name>
</country>
<country name="Australie"><noRegion><name sortKey="Jackson, Katherine J L" sort="Jackson, Katherine J L" uniqKey="Jackson K" first="Katherine J L" last="Jackson">Katherine J L. Jackson</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidStanfordV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000526 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000526 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    CovidStanfordV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:32941787
   |texte=   Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:32941787" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a CovidStanfordV1

This area was generated with Dilib version V0.6.38.
Data generation: Tue Feb 2 21:24:25 2021. Site generation: Tue Feb 2 21:26:08 2021

	Serveur d'exploration sur le Covid à Stanford
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le Covid à Stanford

Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2.

Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki